A SUBSET OF CB002 XANTHINE ANALOGS BYPASS P53-SIGNALING TO RESTORE A P53 TRANSCRIPTOME AND TARGET AN S-PHASE CELL CYCLE CHECKPOINT IN TUMORS WITH MUTATED-P53

Mutations in TP53 occur commonly in the majority of human tumors and confer aggressive tumor phenotypes, including metastasis and therapy resistance.CB002 and structural-analogs restore p53 signaling in tumors with mutant-p53 but we find that unlike other xanthines such as caffeine, pentoxifylline, and theophylline, they do not deregulate the 8.3/8

Primary caregivers Soups are the main mediators of care for children with an autism diagnosis in Canada, and the navigation process to gain access to autism-related services is known to be a major burden.These challenges to service access are compounded for newcomers to Canada, which include immigrants and refugees.The purpose of this scoping revie

Following Karen Barad’s diffractive methodology, we encounter feminist documentary cinema as a diffraction 3m apparatus: that is, as technologies that make part of the world intelligible to another part of the world in specific ways, by means of intra-actions between human and non-human agencies and objects of observation.We propose three ana

The shark fauna (Chondrichthyes: Elasmobranchii) of Pirabas Formation is one of the most representative and diversified of the Neogene of South Shorts America.This fauna is associated with the early Miocene transgression resulting from the global sea level rise.In this paper, the composition of the Pirabas shark fauna is re-evaluated based on new 3

The aim of this research is to find out how to create an electronic header using Flip PDF Professional software.The limited availability of teaching materials in schools causes this problem.Apart from that, e-modules are not technically used as teaching materials by educators.Apart from that, because teachers have not created their little boys trun